Laura Rosenberger

Positions:

Assistant Professor of Surgery

Surgical Oncology
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

B.S. 2003

Eastern Mennonite University

M.D. 2008

Jefferson Medical College of Thomas Jefferson University

General Surgery Resident, Surgery

University of Virginia School of Medicine

Breast Surgical Oncology Fellow, Surgery

Memorial Sloan Kettering Cancer Center

Publications:

The Evolution of Breast Satisfaction and Well-Being after Breast Cancer: A Propensity-Matched Comparison to the Norm.

BACKGROUND: Breast cancer survival continues to improve, with women living longer after treatment. It is not well understood how long-term satisfaction and well-being differ following treatment or how types of reconstruction differ when compared to the norm. METHODS: In a propensity-matched sample, the authors compared patient-reported outcomes in breast cancer patients at various time intervals from surgery with normative BREAST-Q data. All data were obtained using the Army of Women, an online community fostering breast cancer research. Breast cancer patients were stratified by surgical treatment and reconstruction type. Regression lines were estimated and differences in slope tested between cancer patients and noncancer controls. RESULTS: The authors compared normative (n = 922) and breast cancer (n = 4343) cohorts in a propensity-matched analysis. Among the breast cancer patients, 49.4 percent underwent lumpectomy, 17.0 percent underwent mastectomy, 21.7 percent underwent implant reconstruction, and 11.9 percent underwent autologous reconstruction. Median time since surgery was 4.7 years, with 21.1 percent more than 10 years after surgery. At the time of survey, breast cancer patients reported higher Satisfaction with Breasts and Psychosocial Well-being scores compared to noncancer controls (p < 0.01), with the cohorts undergoing lumpectomy and autologous reconstruction both reporting higher scores than the normative controls. After mastectomy, scores averaged lower than the noncancer controls, but improved over time. However, all breast cancer groups reported significantly lower Physical Well-being scores than the noncancer cohort (all p < 0.01). CONCLUSIONS: Breast cancer patients undergoing lumpectomy or autologous reconstruction reported higher psychosocial well-being compared to noncancer controls. These differences were influenced both by time since treatment and by choice of surgical procedure.
Authors
Mundy, LR; Rosenberger, LH; Rushing, CN; Atisha, D; Pusic, AL; Hollenbeck, ST; Hyslop, T; Hwang, ES
MLA Citation
Mundy, Lily R., et al. “The Evolution of Breast Satisfaction and Well-Being after Breast Cancer: A Propensity-Matched Comparison to the Norm.Plast Reconstr Surg, vol. 145, no. 3, Mar. 2020, pp. 595–604. Pubmed, doi:10.1097/PRS.0000000000006535.
URI
https://scholars.duke.edu/individual/pub1432842
PMID
32097289
Source
pubmed
Published In
Plast Reconstr Surg
Volume
145
Published Date
Start Page
595
End Page
604
DOI
10.1097/PRS.0000000000006535

The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed with Intraductal Papilloma without Atypia by Core Needle Biopsy (TBCRC 034)

Authors
Nakhlis, F; Baker, G; Pilewskie, M; Gelman, RS; Calvillo, K; Ludwig, KK; McAuliffe, P; Willey, S; Rosenberger, LH; Parker, C; Gallagher, KK; Jacobs, LK; Feldman, S; Lange, P; DeSantis, SD; Schnitt, SJ; King, TA
MLA Citation
URI
https://scholars.duke.edu/individual/pub1435789
Source
wos
Published In
Annals of Surgical Oncology
Volume
27
Published Date
Start Page
S14
End Page
S14

Germline Genetic Mutations in a Multi-Center Contemporary Cohort of 550 Phyllodes Tumors: An Opportunity for Expanded Multi-Gene Testing

Authors
Rosenberger, LH; Thomas, SM; Nimbkar, SN; Hieken, TJ; Ludwig, KK; Jacobs, LK; Miller, ME; Gallagher, KK; Wong, J; Neuman, HB; Tseng, J; Hassinger, TE; Jakub, JW
MLA Citation
Rosenberger, L. H., et al. “Germline Genetic Mutations in a Multi-Center Contemporary Cohort of 550 Phyllodes Tumors: An Opportunity for Expanded Multi-Gene Testing.” Annals of Surgical Oncology, vol. 27, no. SUPPL 1, SPRINGER, 2020, pp. S106–S106.
URI
https://scholars.duke.edu/individual/pub1435897
Source
wos
Published In
Annals of Surgical Oncology
Volume
27
Published Date
Start Page
S106
End Page
S106

Extent of axillary surgery in inflammatory breast cancer: a survival analysis of 3500 patients.

PURPOSE: Inflammatory breast cancer (IBC) is an aggressive variant for which axillary lymph node (LN) dissection following neoadjuvant chemotherapy (NACT) remains standard of care. But with increasingly effective systemic therapy, it is unclear whether more limited axillary surgery may be appropriate in some IBC patients. We sought to examine whether extent of axillary LN surgery was associated with overall survival (OS) for IBC. METHODS: Female breast cancer patients with non-metastatic IBC (cT4d) diagnosed 2010-2014 were identified in the National Cancer Data Base. Cox proportional hazards modeling was used to estimate the association between extent of axillary surgery (≤ 9 vs ≥ 10 LNs removed) and OS after adjusting for covariates, including post-NACT nodal status (ypN0 vs ypN1-3) and radiotherapy receipt (yes/no). RESULTS: 3471 patients were included: 597 (17.2%) had cN0 disease, 1833 (52.8%) had cN1 disease, and 1041 (30%) had cN2-3 disease. 49.9% of cN0 patients were confirmed to be ypN0 on post-NACT surgical pathology. Being ypN0 (vs ypN1-3) was associated with improved adjusted OS for all patients. Radiotherapy was associated with improved adjusted OS for cN1 and cN2-3 patients but not for cN0 patients. Regardless of ypN status, there was a trend towards improved adjusted OS with having ≥ 10 (vs ≤ 9) LNs removed for cN2-3 patients (HR 0.78, 95% CI 0.60-1.01, p = 0.06) but not for cN0 patients (p = 0.83). CONCLUSIONS: A majority of IBC patients in our study presented with node-positive disease, and for those presenting with cN2-3 disease, more extensive axillary surgery is potentially associated with improved survival. For cN0 patients, however, more extensive axillary surgery was not associated with a survival benefit, suggesting an opportunity for more personalized care.
MLA Citation
Fayanju, Oluwadamilola M., et al. “Extent of axillary surgery in inflammatory breast cancer: a survival analysis of 3500 patients.Breast Cancer Res Treat, vol. 180, no. 1, Feb. 2020, pp. 207–17. Pubmed, doi:10.1007/s10549-020-05529-1.
URI
https://scholars.duke.edu/individual/pub1428164
PMID
31960171
Source
pubmed
Published In
Breast Cancer Res Treat
Volume
180
Published Date
Start Page
207
End Page
217
DOI
10.1007/s10549-020-05529-1

Influence of bronchoscopy on the diagnosis of and outcomes from ventilator-associated pneumonia.

BACKGROUND: Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection affecting as many as 27% of mechanically ventilated patients. Ventilator-associated pneumonia is an important source of morbidity and mortality in the surgical intensive care unit (SICU). The optimal diagnostic method for VAP has remained controversial and the role of therapeutic bronchoscopy in the clearance of pulmonary secretions with VAP, in essence source control, remains unknown. Our unit utilizes bronchoscopy inconsistently for these purposes and we chose to evaluate its effectiveness in our patient population with the hypothesis that bronchoscopic diagnosis and therapy results in lower mortality rates and faster clinical resolution. METHODS: We analyzed retrospectively all patients treated for VAP in a single SICU between September 2003 and December 2011. Patients were divided into groups based upon diagnostic method and receipt of therapeutic bronchoscopy, and were analyzed for differences in time to clinical resolution and mortality. RESULTS: A total of 360 patients were included in the study, including 493 episodes of VAP. The diagnostic bronchoscopy group had statistically higher APACHE II scores (p=0.02) and fewer days in hospital prior to diagnosis (p=0.02) when compared with the non-invasive diagnosis group. Diagnostic bronchoscopy was associated with shorter length of stay and shorter duration of antibiotics whereas receipt of a therapeutic bronchoscopy was associated with the opposite effects by multivariable analysis. CONCLUSION: Our hypothesis was disproved and our findings are similar to those found in recent publications. This study supports no definitive conclusions, but further consideration of the role of bronchoscopy is urged in both the diagnosis and treatment of VAP. In our population, bronchoscopy for diagnostic or therapeutic purposes in VAP was not associated with better outcomes. However, differences in baseline characteristics suggest a randomized trial may be needed to answer more completely this question.
Authors
Guidry, CA; Mallicote, MU; Petroze, RT; Hranjec, T; Rosenberger, LH; Davies, SW; Sawyer, RG
MLA Citation
Guidry, Christopher A., et al. “Influence of bronchoscopy on the diagnosis of and outcomes from ventilator-associated pneumonia.Surg Infect (Larchmt), vol. 15, no. 5, Oct. 2014, pp. 527–32. Pubmed, doi:10.1089/sur.2013.142.
URI
https://scholars.duke.edu/individual/pub1148992
PMID
24841750
Source
pubmed
Published In
Surg Infect (Larchmt)
Volume
15
Published Date
Start Page
527
End Page
532
DOI
10.1089/sur.2013.142