Taewoong Choi

Overview:

Based on my prior experience in basic/translational immunology research and clinical hematopoietic stem cell transplantation, I am interested in early phase clinical protocols for novel immunotherapy of hematologic malignancies.

Positions:

Medical Instructor in the Department of Medicine

Medicine, Hematologic Malignancies and Cellular Therapy
School of Medicine

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine

Education:

M.D. 2002

Seoul National University

Internship and Residency in Internal Medicine

St. Luke's Memorial Hospital Center

Hematology/Oncology Fellowship

University of Pittsburgh School of Medicine

BMT Fellowship

Stanford University School of Medicine

Postdoctoral Research Fellow on T32 Training Grant

Stanford University School of Medicine

Grants:

JZP395-201

Administered By
Duke Cancer Institute
Role
Principal Investigator
Start Date
End Date

Publications:

Is autologous stem cell transplantation still relevant for multiple myeloma?

PURPOSE OF REVIEW: Autologous stem cell transplantation has been the standard of care in myeloma treatment for many years, but the availability of newer antimyeloma drugs and the emerging data from chimeric antigen receptor (CAR) T-cell clinical studies make us question the relevance of it. The purpose of this review is to go over recent data and to reassess the current status of autologous stem cell transplantation as a standard of care. RECENT FINDINGS: Autologous stem cell transplantation can be safely performed for elderly patients and there is no absolute age limit. Recent data on BEAM (Carmustine, Etoposide, Cytarabine, and Melphalan), Busulfan/Melphalan, and Carmustine/Melphalan conditioning when compared with Melphalan showed favorable survival outcomes with manageable toxicities although we need to see data from randomized, multicenter studies. Posttransplant maintenance and consolidation can maximize the benefit of transplant by prolonging progression-free survival. Current B-cell maturation antigen CAR T-cell therapy showed remarkably high response rates, but didn't seem to provide durable response yet. SUMMARY: Recent advances in myeloma therapy and autologous stem cell transplantation are described. Although we've seen many new developments including CAR T-cell therapies, autologous stem cell transplantation remains as the standard of care. However, it may be replaced by or combined with newer therapies in the future.
Authors
MLA Citation
Choi, Taewoong. “Is autologous stem cell transplantation still relevant for multiple myeloma?.” Curr Opin Hematol, vol. 26, no. 6, Nov. 2019, pp. 386–91. Pubmed, doi:10.1097/MOH.0000000000000538.
URI
https://scholars.duke.edu/individual/pub1411540
PMID
31567432
Source
pubmed
Published In
Curr Opin Hematol
Volume
26
Published Date
Start Page
386
End Page
391
DOI
10.1097/MOH.0000000000000538

RE: Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma

Authors
Diwakar, D; Choi, T; Tawbi, TH; Kirkwood, JM
MLA Citation
Diwakar, D., et al. “RE: Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma.” Annals of Oncology, vol. 25, no. 8, Elsevier BV, Aug. 2014, pp. 1670–71. Crossref, doi:10.1093/annonc/mdu196.
URI
https://scholars.duke.edu/individual/pub1271144
Source
crossref
Published In
Annals of Oncology
Volume
25
Published Date
Start Page
1670
End Page
1671
DOI
10.1093/annonc/mdu196

Ly49-Dependent NK Cell Licensing and Effector Inhibition Involve the Same Interaction Site on MHC Ligands

Authors
Choi, T; Ferris, ST; Matsumoto, N; Poursine-Laurent, J; Yokoyama, WM
MLA Citation
Choi, Taewoong, et al. “Ly49-Dependent NK Cell Licensing and Effector Inhibition Involve the Same Interaction Site on MHC Ligands.” The Journal of Immunology, vol. 186, no. 7, The American Association of Immunologists, Apr. 2011, pp. 3911–17. Crossref, doi:10.4049/jimmunol.1004168.
URI
https://scholars.duke.edu/individual/pub1271143
Source
crossref
Published In
The Journal of Immunology
Volume
186
Published Date
Start Page
3911
End Page
3917
DOI
10.4049/jimmunol.1004168

Sociocultural Determinants of Negative Emotions Among Dementia Caregivers in the United States and in Korea: A Content Analysis of Online Support Groups

Authors
Yoo, JH; Jang, SA; Choi, T
MLA Citation
Yoo, Jina H., et al. “Sociocultural Determinants of Negative Emotions Among Dementia Caregivers in the United States and in Korea: A Content Analysis of Online Support Groups.” Howard Journal of Communications, vol. 21, no. 1, Informa UK Limited, Jan. 2010, pp. 1–19. Crossref, doi:10.1080/10646170903501195.
URI
https://scholars.duke.edu/individual/pub1271095
Source
crossref
Published In
Howard Journal of Communications
Volume
21
Published Date
Start Page
1
End Page
19
DOI
10.1080/10646170903501195

HLA alleles determine differences in human natural killer cell responsiveness and potency

Authors
Kim, S; Sunwoo, JB; Yang, L; Choi, T; Song, Y-J; French, AR; Vlahiotis, A; Piccirillo, JF; Cella, M; Colonna, M; Mohanakumar, T; Hsu, KC; Dupont, B; Yokoyama, WM
MLA Citation
Kim, S., et al. “HLA alleles determine differences in human natural killer cell responsiveness and potency.” Proceedings of the National Academy of Sciences, vol. 105, no. 8, Proceedings of the National Academy of Sciences, Feb. 2008, pp. 3053–58. Crossref, doi:10.1073/pnas.0712229105.
URI
https://scholars.duke.edu/individual/pub1271094
Source
crossref
Published In
Proceedings of the National Academy of Sciences of the United States of America
Volume
105
Published Date
Start Page
3053
End Page
3058
DOI
10.1073/pnas.0712229105

Research Areas:

Cellular therapy
Immunotherapy
Multiple Myeloma
Plasma cell diseases
Stem Cell Transplantation